Status:
COMPLETED
Salt Loading and Thiazide Intervention Study
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Hypertension
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
The investigators of this study propose to examine the relationships between STK39 (Serine Threonine Kinase 39) genotypes and responses to salt loading and to thiazide diuretics, hydrochlorothiazide. ...
Detailed Description
Although hypertension can be easily diagnosed and there are many medications available to treat hypertension, this condition is poorly managed in many patients and is a leading cause of morbidity and ...
Eligibility Criteria
Inclusion
- Old Order Amish
- Age 18 to 65
- Have systolic blood pressure between 120 and 160 and diastolic blood pressure between 80 and 100
Exclusion
- History of myocardial infarction, stroke, congestive heart failure, liver disease
- Known cause of secondary hypertension
- Diabetes or Fasting glucose \> 100 mg/dL
- Women who are pregnant, on oral contraceptives, or menstruating
- Used hydrochlorothiazide (HCTZ) in the last 8 weeks or known allergy to HCTZ
- Taking non-steroidal anti-inflammatory drugs
- Estimated glomerular filtration rate \< 80 mL/m
- Intention to alter dietary habit during the study
- Abuse of alcohol or drug
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2013
Estimated Enrollment :
124 Patients enrolled
Trial Details
Trial ID
NCT00896389
Start Date
October 1 2009
End Date
March 1 2013
Last Update
March 25 2022
Active Locations (1)
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1
Amish Research Clinics
Lancaster, Pennsylvania, United States, 17607