Status:
COMPLETED
Laboratory Study of Lymphoblasts in Young Patients With High-Risk Acute Lymphoblastic Leukemia
Lead Sponsor:
Children's Oncology Group
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Leukemia
Eligibility:
All Genders
1-21 years
Brief Summary
RATIONALE: Collecting and storing samples of bone marrow and blood from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify bio...
Detailed Description
OBJECTIVES: * Identify regions of copy number abnormalities (CNA) and uniparental disomy in leukemic lymphoblasts from pediatric patients with high-risk acute lymphoblastic leukemia (ALL) using Affym...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Diagnosis of B-cell precursor acute lymphoblastic leukemia (ALL)
- High-risk disease
- Participation in clinical trial COG-P9906 required (pilot project)
- In complete remission
- Consented to future studies using banked tissue specimens
- Participation in clinical trial and COG-AALL03B1 and linked therapeutic studies COG-AALL0232 and COG- AALL0331(expansion project)
- Experienced a bone marrow relapse within 36 months of initial diagnosis
- Consented to future studies using banked tissue specimens
- Have matched ALL blast and germline specimens
- Demographic, clinical and pathologic data elements for these biospecimens available
- PATIENT CHARACTERISTICS:
- Not specified
- PRIOR CONCURRENT THERAPY:
- Not specified
Exclusion
Key Trial Info
Start Date :
May 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2016
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT00896766
Start Date
May 1 2006
End Date
May 1 2016
Last Update
May 17 2016
Active Locations (1)
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1
Hollings Cancer Center at Medical University of South Carolina
Charleston, South Carolina, United States, 29425