Status:
WITHDRAWN
Studying Cerebrospinal Fluid Proteins and Angiogenesis Proteins in Young Patients With Newly Diagnosed Central Nervous System Tumors
Lead Sponsor:
Pediatric Brain Tumor Consortium
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Brain and Central Nervous System Tumors
Eligibility:
All Genders
Up to 21 years
Brief Summary
RATIONALE: Studying samples of cerebrospinal fluid from patients with cancer in the laboratory may help doctors identify biomarkers related to cancer. PURPOSE: This laboratory study is studying cereb...
Detailed Description
OBJECTIVES: Primary * Investigate the feasibility of centrally collecting and processing high-quality cerebrospinal fluid (CSF) samples from pediatric patients with newly diagnosed central nervous s...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Histologically confirmed CNS tumors of any of the following histologies:
- Diffuse pontine gliomas\*
- Focal/infiltrative tumors, including any of the following:
- High- and low-grade gliomas
- Gangliogliomas
- Ependymomas
- Oligodendrogliomas
- Craniopharyngioma
- Dysembryoplastic neuroepithelial tumors
- Other low-grade neoplasms
- Optic pathway gliomas\*
- Seeding tumors, including any of the following:
- Germ cell tumors (germinomas and nongerminomas)
- Embryonal tumors, including any of the following:
- Medulloblastoma
- Pineoblastoma
- Supratentorial primitive neuroectodermal tumors
- Atypical teratoid/rhabdoid tumor
- Other embryonal tumors NOTE: \*Histological requirement waived
- Newly diagnosed disease
- Cerebrospinal fluid (CSF) obtained as part of CSF diversion, initial diagnosis/staging, or administration of intrathecal chemotherapy (at the initiation of postoperative therapy)
- PATIENT CHARACTERISTICS:
- Less than 22 years of age
- PRIOR CONCURRENT THERAPY:
- No prior radiotherapy or chemotherapy
- Prior corticosteroids allowed
Exclusion
Key Trial Info
Start Date :
August 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00897858
Start Date
August 1 2006
Last Update
April 19 2013
Active Locations (8)
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1
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010-2970
2
Children's Memorial Hospital - Chicago
Chicago, Illinois, United States, 60614
3
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02115
4
Duke Comprehensive Cancer Center
Durham, North Carolina, United States, 27710