Status:
UNKNOWN
Studying Blood Samples in Young Patients With Cytopenia After a Donor Stem Cell Transplant
Lead Sponsor:
European Working Group of MDS in Childhood
Conditions:
Leukemia
Myelodysplastic Syndromes
Eligibility:
All Genders
Up to 17 years
Brief Summary
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This r...
Detailed Description
OBJECTIVES: Primary * To study hematopoietic chimerism in whole blood and different cell populations (i.e., CD14, CD15, CD 56, CD3, and CD19) as well as in dendritic cells and regulatory T cells aft...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Diagnosed with refractory cytopenia
- Hypocellular bone marrow and normal karyotype
- Underwent stem cell transplantation (SCT) from an HLA identical (8/8) sibling, an HLA identical (10/10) relative, or an HLA identical or single allelic disparate unrelated donor
- Received a preparative regimen including either thiotepa or fludarabine phosphate
- Concurrently enrolled on EWOG-MDS-2006
- PATIENT CHARACTERISTICS:
- Not specified
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Exclusion
Key Trial Info
Start Date :
April 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
125 Patients enrolled
Trial Details
Trial ID
NCT00898118
Start Date
April 1 2007
Last Update
August 12 2013
Active Locations (10)
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1
St. Anna Children's Hospital
Vienna, Austria, A-1090
2
Ghent University
Ghent, Belgium, B-9000
3
University Hospital Motol
Prague, Czechia, 150 06
4
Aarhus Universitetshospital - Aarhus Sygehus
Aarhus, Denmark, DK-8000