Status:
COMPLETED
Capsule Endoscopy to Screen for Small Bowel Neoplasia in Lynch Syndrome
Lead Sponsor:
University Medical Center Groningen
Collaborating Sponsors:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Erasmus Medical Center
Conditions:
Lynch Syndrome
Small Bowel Neoplasia
Eligibility:
All Genders
35-70 years
Phase:
EARLY_PHASE1
Brief Summary
Lynch syndrome (LS), or hereditary nonpolyposis colorectal cancer (HNPCC), is a hereditary disorder characterized by a very high risk of early-onset colorectal and endometrial cancer and an increased ...
Detailed Description
Lynch syndrome (LS), or hereditary nonpolyposis colorectal cancer (HNPCC), is an autosomal dominantly inherited disorder characterized by a very high risk of early-onset colorectal and endometrial can...
Eligibility Criteria
Inclusion
- Asymptomatic proven mutation carriers, with a known mutation in the hMLH1, hMSH2 or hMSH6 gene.
- Age between 35 and 70 years.
- Written informed consent provided.
Exclusion
- Subjects with a strong suspicion on a small bowel stricture.
- Subjects with previous small bowel surgery.
- Pregnancy.
- Presence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule.
Key Trial Info
Start Date :
May 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00898768
Start Date
May 1 2009
End Date
December 1 2014
Last Update
December 9 2014
Active Locations (1)
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1
University Medical Center Groningen
Groningen, Netherlands