Status:
COMPLETED
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction
Lead Sponsor:
University Medical Center Groningen
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
40-75 years
Brief Summary
Despite emerging implications for ADAMs (and matrix metalloproteinases (MMPs)) in disease progression, the mechanisms that lead to activation of specific ADAMs (and MMPs) and their actions in chronic ...
Detailed Description
Smoking is the largest risk factor for the development of COPD. It has been shown in patients with COPD that smoking induces airway inflammation characterized by bronchial infiltration of neutrophils,...
Eligibility Criteria
Inclusion
- Age between 40 and 75 years.
- Individuals who currently smoke ≥ 10 cigarettes/day and \> 10 pack years.
- Documented FEV1 \> 80% predicted, FEV1/FVC \> 70%.
- Referred by own physician for a bronchoscopy.
Exclusion
- Any disease that, as judged by the Investigator, could affect the outcome of this study.
- A respiratory tract infection within 4 weeks of the start of the study.
- History of myocardial infarction or documented myocardial ischemia or the presence of an artificial heart valve.
- Use of anticoagulants.
Key Trial Info
Start Date :
May 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00898859
Start Date
May 1 2009
End Date
December 1 2012
Last Update
January 16 2015
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