Status:
COMPLETED
Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer
Lead Sponsor:
University Hospital, Grenoble
Conditions:
Colorectal Cancer
Metastatic Cancer
Eligibility:
All Genders
18+ years
Brief Summary
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help...
Detailed Description
OBJECTIVES: Primary * Describe the kinetics of postoperative changes of serum matrix metalloproteinases (MMP) (MMP-1, MMP-2, MMP-7, MMP-9) and their inhibitors (TIMP) (TIMP-1, TIMP-2) as a function ...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Meets 1 of the following criteria:
- Patients with histologically confirmed adenocarcinoma of the colon or rectum and liver metastases
- Must have undergone prior complete resection of the tumor more than 3 months ago
- Liver metastases must be resectable or accessible for radiofrequency ablation
- Patients undergoing cryosurgery of the digestive tract for a reason other than cancer or infection (control)
- PATIENT CHARACTERISTICS:
- No other neoplastic disease that is measurable or being treated other than colorectal cancer
- No heart failure or severe respiratory disease
- No uncontrolled infection or other severe disease
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No participation in another study involving new drugs
Exclusion
Key Trial Info
Start Date :
September 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT00899210
Start Date
September 1 2003
Last Update
May 17 2011
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