Status:
UNKNOWN
Mesothelin and Osteopontin as Diagnostic Markers in Patients With Mesothelioma or Atypical Mesothelial Hyperplasia
Lead Sponsor:
University Hospital, Caen
Conditions:
Malignant Mesothelioma
Metastatic Cancer
Eligibility:
All Genders
Brief Summary
RATIONALE: Studying levels of mesothelin and osteopontin in samples of blood from patients with mesothelioma or atypical mesothelial hyperplasia may help doctors identify biomarkers related to cancer....
Detailed Description
OBJECTIVES: Primary * Determine if mesothelin and osteopontin in serum can serve as early markers of malignant transformation into mesothelioma. Secondary * Determine if there are cytological, his...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Inclusion criteria:
- Diagnosis of mesothelial hyperplasia and meeting 1 of the following criteria:
- Confirmed prior exposure to asbestos and presence of pleural effusion and meets 1 of the following diagnostic criteria:
- Mesothelioma
- Mesothelial hyperplasia of unspecified malignancy
- Reactional inflammatory hyperplasia
- No asbestos exposure but pleural effusion with pleural malignant mesothelioma or pulmonary metastasis
- Prior exposure to asbestos, no pleural effusion, and asymptomatic (pleural plaques present)
- No prior exposure to asbestos but with benign pleural effusion
- Tissue obtained by pleuroscopy, surgical biopsy, or video-thoracoscopy available
- Paraffin-embedded and frozen tissue available
- Exclusion criteria:
- Solitary fibrous tumor
- Diffuse pleural fibrosis
- Purulent pleurisy
- PATIENT CHARACTERISTICS:
- Not specified
- PRIOR CONCURRENT THERAPY:
- No prior chemotherapy or radiotherapy
Exclusion
Key Trial Info
Start Date :
April 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
270 Patients enrolled
Trial Details
Trial ID
NCT00899613
Start Date
April 1 2007
Last Update
December 15 2009
Active Locations (1)
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1
CHU de Caen
Caen, France, 14033