Status:
COMPLETED
UMCC 003 Cancer-Related Protein Biomarkers in Blood and Tumor Tissue of Patients With Cancer
Lead Sponsor:
University of Michigan Rogel Cancer Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Breast Cancer
Colorectal Cancer
Eligibility:
All Genders
18+ years
Brief Summary
RATIONALE: Studying samples of blood and tumor tissue in the laboratory from patients with cancer and blood from healthy participants may help doctors learn more about changes that may occur in DNA an...
Detailed Description
OBJECTIVES: * Identify tumor antigens that induce a humoral response in patients with cancer. * Identify tumor-secreted proteins by special analysis in culture, and evaluate their expression patterns...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Meets 1 of the following criteria (patient):
- Scheduled to undergo primary surgical resection or first debulking surgery (prior to any anticancer treatment) for suspected or newly diagnosed cancer, including any of the following types:
- Breast cancer
- Adenocarcinoma of the colon
- Adenocarcinoma or squamous cell carcinoma of the esophagus
- Non-small cell lung cancer
- Ovarian epithelial adenocarcinoma
- Metastatic or unresectable cancer, including any of the following types:
- Breast cancer
- Adenocarcinoma of the colon
- Adenocarcinoma or squamous cell carcinoma of the esophagus
- Hepatoma
- Non-small cell lung cancer
- Small cell lung cancer
- Ovarian epithelial adenocarcinoma
- Adenocarcinoma of the pancreas
- Meets the following criteria (healthy participant):
- No chronic disease
- Healthy participants with a history of cancer must be cancer-free for 5 years (skin cancer or carcinoma in situ of the cervix within the past 5 years allowed)
- Willing to provide 60 mL of blood
- Not a blood relative of an eligible and consenting cancer patient
- PATIENT CHARACTERISTICS:
- Able to tolerate the removal of 30-60 mL of blood
- No feelings of light-headedness, dizziness, or fainting within the past 2 weeks
- Pulse less than 100 on day of blood draw for study enrollment
- PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- At least 3 weeks since prior chemotherapy or radiotherapy for metastatic or unresectable cancer
- No concurrent chemotherapy
- No concurrent radiotherapy
Exclusion
Key Trial Info
Start Date :
June 1 2000
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2007
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT00900094
Start Date
June 1 2000
End Date
October 1 2007
Last Update
February 7 2012
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