Status:
COMPLETED
Studying Tissue Samples to Learn More About Drug Resistance in Patients With Acute Myeloid Leukemia
Lead Sponsor:
ECOG-ACRIN Cancer Research Group
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Leukemia
Eligibility:
All Genders
18-120 years
Brief Summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about cancer and the development of drug resistance in patients. PURPOSE: This laboratory...
Detailed Description
OBJECTIVES: * Ascertain whether assessments of P-glycoprotein (P-gp) status using the accumulation assay find greater than 10% positive specimens among 30 specimens (collected from patients with acut...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Cryopreserved bone marrow specimens collected from patients with acute myeloid leukemia enrolled on clinical trial ECOG-E3999 meeting the following criteria:
- Appreciable levels of either CD34+ OR CD117+ blasts
- Appreciable staining with anti-P-gp antibodies
- 30 specimens must exhibit low to moderate dye loading for the Rh123 efflux assay
- 10 specimens must exhibit positive Rh123 efflux activities
- PATIENT CHARACTERISTICS:
- Not specified
- PRIOR CONCURRENT THERAPY:
- Not specified
Exclusion
Key Trial Info
Start Date :
March 28 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 30 2013
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00900380
Start Date
March 28 2006
End Date
December 30 2013
Last Update
May 19 2017
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