Status:
UNKNOWN
Evolution of Memory Related Activity
Lead Sponsor:
National Institute on Aging (NIA)
Conditions:
Alzheimer's Disease
Mild Cognitive Impairment
Eligibility:
All Genders
55-90 years
Brief Summary
The purpose of this study is to begin the process of validating fMRI (functional magnetic resonance imaging) as a biomarker for use in clinical trials and longitudinal studies of clinical progression ...
Detailed Description
The development of biomarkers is now especially critical, as there are a number of promising disease-modifying therapies entering early phase clinical trials, with additional novel therapeutic strateg...
Eligibility Criteria
Inclusion
- Ages 55-90
- General good health or stable medical problems
- Study partner/caregiver able to provide an independent evaluation of the participant's daily functioning
- No contraindications to MR scanning
- Modified Hachinski Ischemic Score ≤4
- Geriatric Depression Scale ≤10
Exclusion
- Diagnosis of Parkinson's disease or other neurological illness
- Presence of clinically significant/uncontrolled medical conditions
- History of stroke, brain tumor, brain surgery, seizures, significant head trauma with loss of consciousness, depression or other psychiatric illness, alcohol or drug abuse in the past 2 years
- Significant uncorrectable visual impairment
Key Trial Info
Start Date :
May 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2011
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT00902499
Start Date
May 1 2006
End Date
May 1 2011
Last Update
July 26 2010
Active Locations (2)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
2
Massachusetts General Hospital
Boston, Massachusetts, United States, 02129