Status:
COMPLETED
Effect of Arginine on Microcirculation in Patients With Diabetes
Lead Sponsor:
Tameside Hospital NHS Foundation Trust
Conditions:
Type 2 Diabetes
Eligibility:
All Genders
30-65 years
Phase:
PHASE4
Brief Summary
Patients with diabetes have dysfunction of the lining of the arteries which lead to impaired circulation in the small blood vessels. This is thought to be secondary to reduced chemicals in the blood v...
Detailed Description
Peripheral neuropathy is one of the most common complications of diabetes mellitus (DM) with a prevalence of around 30 - 45%. In addition, diabetic patients are at increased risk of macrovascular dise...
Eligibility Criteria
Inclusion
- Males and females diabetic patients with peripheral neuropathy, aged 30-65 years
- Type 2 diabetes (NIDDM) judged by WHO criteria:
- onset of diabetes mellitus after the age of 30 years
- not requiring insulin for control of diabetes or insulin treatment initiated after one year diagnosis of diabetes
- no history of diabetic ketoacidosis
- All patients will have detailed history and physical examination
Exclusion
- Patients with ischaemic heart disease
- Previous stroke and severe peripheral vascular disease)
- Previous amputation
- Renal failure (defined as serum creatinine \> 120 mmol/l)
- Uncontrolled hypertension (BP \> 160/90)
- Patients on nitrates
Key Trial Info
Start Date :
June 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2006
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00902616
Start Date
June 1 2003
End Date
June 1 2006
Last Update
November 27 2013
Active Locations (1)
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1
Tameside General Hospital
Ashton-under-Lyne, Cheshire, United Kingdom, OL6 9RW