Status:
COMPLETED
Steroid Sparing Effect of Nasal Corticosteroid In Asthma And Rhinitis
Lead Sponsor:
University of Dundee
Conditions:
Asthma
Allergic Rhinitis
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
Up to 40% of patients with asthma have allergic rhinitis and treatment of nasal airway inflammation with topical steroids improves the twitchiness of the airways (hyperresponsiveness) and overall asth...
Eligibility Criteria
Inclusion
- Mild to moderate atopic asthmatics with FEV1 ≥ 60% on ≤ 1000 ug BDP and concomitant persistent allergic rhinitis (SPT +ve and PC20 \< 4 mg/ml)
- Male or female aged 18-65 years
- Informed Consent
- Ability to comply with the requirements of the protocol
Exclusion
- Severe asthmatics as defined by an FEV1 ≤ 60% or PEF variability \> 30% or with continual daytime or nocturnal symptoms.
- Nasal Polyposis grade 2/3, deviated nasal septum ≥ 50%
- The use of oral corticosteroids within the last 3 months
- Recent respiratory tract infection (2 months)
- Significant concomitant respiratory disease
- Any other significant medical condition or investigation which may jeopardise the safety of the participant or the conduct of the protocol
- Any significant abnormal laboratory result as deemed by the investigators
- Pregnancy, planned pregnancy or lactation
- Known or suspected contra-indication to any of the IMP's
- Concomitant use of medicines (prescribed, over the counter or herbal) that may interfere with the trial
Key Trial Info
Start Date :
December 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2008
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00903227
Start Date
December 1 2006
End Date
August 1 2008
Last Update
October 16 2019
Active Locations (1)
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1
Asthma and Allergy Research Group, Ninewells Hospital and University of Dundee
Dundee, Angus, United Kingdom, DD1 9SY