Status:
COMPLETED
Mucus Dehydration and Evolution of Chronic Obstructive Pulmonary Disease (COPD) Lung Disease
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborating Sponsors:
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Chronic Obstructive Pulmonary Disease
Chronic Bronchitis
Eligibility:
All Genders
18-82 years
Brief Summary
The purpose of this research is to understand the properties of mucus in persons with COPD, specifically Chronic Bronchitis. We hypothesize that those with Chronic Bronchitis have dehydrated mucus, an...
Detailed Description
Specific Aim I directly tests the hypothesis that mucus clearance is impaired due to mucus dehydration. It measures 1) COPD Mucociliary and Cough Clearance 2) mucus hydration 3) the concentrations of ...
Eligibility Criteria
Inclusion
- history of COPD/chronic bronchitis defined as having a productive cough for three months of the year for at least two successive years
- greater than or equal to a 10 pack year cigarette smoking history
- ability to perform spirometry
Exclusion
- unstable lung disease
- allergy to study medications
- radiation exposure within past year exceeding Federal Regulation Limits
Key Trial Info
Start Date :
September 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2012
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00903955
Start Date
September 1 2006
End Date
March 1 2012
Last Update
February 7 2013
Active Locations (1)
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1
University of North Carolina Chapel Hill
Chapel Hill, North Carolina, United States, 27599