Status:
COMPLETED
Study of the Molecular Genetics of Menstrual Migraine
Lead Sponsor:
The City of London Migraine Clinic
Collaborating Sponsors:
Griffith University
Conditions:
Migraine
Eligibility:
FEMALE
18+ years
Brief Summary
The investigators hypothesize that genes that play a role in menstrual migraine can be identified using a well characterised migraine population and a comprehensive genome-wide association scan approa...
Eligibility Criteria
Inclusion
- All cases and controls must:
- Be over 18 years
- Caucasian
- Provide written, informed consent
- Clearly understand and be able to comply with all the trial procedures, as required
- Not have taken part in trials of any investigational products within the previous 4 weeks
- DNA Study:
- Cases must have at least a 12-month current or past history of menstrual migraine
- RNA Study:
- Cases must have at least a 12-month current history of menstrual migraine
- Cases must have kept at least three months of headache diary data in advance of visit in order to confirm diagnosis
- Controls must still be having menstrual periods
Exclusion
- DNA Study:
- Cases and controls must not have smoked, chewed gum or consumed any food or drink in the 30 minutes prior to sample collection
- RNA Study:
- Cases and controls will not be eligible for participation if they have:
- Polycystic ovarian syndrome;
- Taken any hormones or drugs in the previous three months that may affect normal hormone activity (e.g., hormonal contraceptives, hormone replacement therapy, dietary supplements such as isoflavones);
- Donated or lost a significant amount of blood (\> 550 mL) within the previous 12 weeks
- Additionally, controls must not have a personal or family history in any first-degree relative of current or past migraine
Key Trial Info
Start Date :
November 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2013
Estimated Enrollment :
585 Patients enrolled
Trial Details
Trial ID
NCT00904150
Start Date
November 1 2007
End Date
August 1 2013
Last Update
February 24 2014
Active Locations (1)
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1
The City of London Migraine Clinic
London, United Kingdom, EC1M 6DX