Status:
COMPLETED
Simvastatin Effect on Inflammation and Endothelial Function After Myocardial Infarction
Lead Sponsor:
Brasilia Heart Study Group
Conditions:
Myocardial Infarction
Inflammation
Eligibility:
All Genders
45-70 years
Phase:
PHASE4
Brief Summary
During myocardial infarction, inflammatory response may negatively influence ventricle wall remodeling as well as endothelium-dependent vasomotor function in the coronary and systemic arterial systems...
Detailed Description
During acute coronary syndromes (ACS), the generation of inflammatory mediators negatively influences arterial wall remodeling and the endothelium-dependent vasomotor function in the coronary and syst...
Eligibility Criteria
Inclusion
- Less than 24 hours after the onset of MI symptoms
- ST-segment elevation of a least 1 mm (frontal plane) or 2 mm (horizontal plane) in two contiguous leads
- Myocardial necrosis, as evidenced by increased CK-MB and troponin levels
Exclusion
- Use of statins for at least 6 months prior the myocardial infarction
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2009
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT00906451
Start Date
November 1 2008
End Date
May 1 2009
Last Update
June 23 2011
Active Locations (1)
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1
Hospital de Base do Distrito Federal
Brasília, Federal District, Brazil, 70000000