Status:
COMPLETED
Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)
Lead Sponsor:
University of Wisconsin, Madison
Conditions:
Anosognosia
Alzheimer's Disease
Eligibility:
All Genders
60-90 years
Brief Summary
This is a three year fMRI study conducted at the University of Wisconsin (UW) Hospital and the William. S. Middleton VA Hospital. This study is guided by the hypothesis that reduced fMRI activity and ...
Eligibility Criteria
Inclusion
- Amnestic MCI:
- Observation of memory decline by informant.
- Mini Mental Status Exam (MMSE) score between 24 and 30.
- Objective memory impairment on neuropsychological tests.
- Intact functional abilities, and 4) no diagnosis of dementia.
- AD:
- A diagnosis of probable AD according with the NINDS-ADRDA and DSM-IV diagnostic criteria.
- MMSE score between 16 and 27. All AD patients will have capacity to provide informed consent as judged by the referring physician.
Exclusion
- MRI incompatibility; history of neurologic disease (including prior loss of consciousness of more than 10 minutes); prior neurosurgery; or chronic medical diseases (such as poorly controlled diabetes, renal disease, or poorly controlled hypertension).
- Excluded medications include neuroleptics, short or long acting nitrates, and Warfarin.
- Other exclusions include: less than 10 yrs of education; Hachinski scale of 4 or more; first language other than English; poor visual or auditory acuity; pregnancy.
Key Trial Info
Start Date :
April 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2011
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00908999
Start Date
April 1 2008
End Date
September 1 2011
Last Update
September 29 2011
Active Locations (1)
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1
William S Middleton VA Hospital GRECC
Madison, Wisconsin, United States, 53705