Status:
COMPLETED
Healthy Volunteers Study of the Effects of Olanzapine and Ziprasidone
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
Pfizer
Conditions:
Hyperglycemia
Hyperlipidemia
Eligibility:
MALE
18-45 years
Phase:
NA
Brief Summary
Primary Aim: To test the acute effects of olanzapine or ziprasidone administration, in comparison to placebo, on insulin sensitivity in antipsychotic-naïve healthy young men, measured as whole-body de...
Detailed Description
See brief description
Eligibility Criteria
Inclusion
- Males aged 18-45 years
- BMI approximately ≥ 25 and \< 35
- insulin approximately ≥ 15 µU/ml or triglyceride approximately ≥ 130 mg/dl
Exclusion
- Any DSM-IV Axis I diagnosis
- prisoners
- any serious medical disorder (i.e. metabolic diseases, type 1 or 2 diabetes mellitus, endocrine disease, coagulopathy, clinically significant anemia, acute infection)
- taking prescription medications
- non-sedentary lifestyle with \> 3 hours of exercise per week
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT00910988
Start Date
February 1 2009
End Date
June 1 2012
Last Update
July 18 2018
Active Locations (1)
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1
Washington University School of Medicine
St Louis, Missouri, United States, 63110