Status:
COMPLETED
Study Comparing High Cut-off Haemofiltration With Standard Haemofiltration in Acute Renal Failure
Lead Sponsor:
Austin Health
Conditions:
Kidney Failure, Acute
Shock
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
This trial aims to study the effect of combining continuous and a new polyamide membrane with larger pores in the treatment of critically ill patients with acute renal failure and low blood pressure (...
Detailed Description
During acute renal failure, small and middle molecular-weight toxins accumulate. These molecules are difficult to remove by standard haemofiltration. Accordingly, they accumulate and contribute to mor...
Eligibility Criteria
Inclusion
- The treating clinician believes that the patient requires haemofiltration for acute renal failure
- The patient is on noradrenaline infusion for haemodynamic support
- The patient was commenced on noradrenaline or haemofiltration within the last 12 hours
- The clinician is uncertain about the balance of benefits and risks likely to be conferred by treatment with different membranes
- The treating clinicians anticipate treating the patient with haemofiltration for at least 72 hours
- Informed consent has been obtained
- The patient fulfils ONE of the following clinical criteria for initiating haemofiltration:
- Oliguria (urine output \< 100 ml/6 hr) that has been unresponsive to fluid resuscitation measures.
- Hyperkalemia (\[K+\] \> 6.5 mmol/L)
- Severe acidemia (pH \< 7.2)
- Urea \> 25 mmol/liter
- Creatinine \> 300 mmol/L
- Clinically significant organ oedema in the setting of ARF (e.g., lung)
Exclusion
- Patient age is \< 18 years
- Death is imminent (\< 24 hours)
- There is a strong likelihood that the study treatment would not be continued in accordance with the study protocol
- The patient has been treated with haemofiltration or other dialysis previously during the same hospital admission
- The patient was on maintenance dialysis prior to the current hospitalisation
- Any other major illness that, in the investigator's judgment, will substantially increase the risk associated with the subject's participation in this study
- The patient is pregnant or is breastfeeding
- The patient has previously been enrolled in this study
Key Trial Info
Start Date :
May 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2012
Estimated Enrollment :
76 Patients enrolled
Trial Details
Trial ID
NCT00912184
Start Date
May 1 2009
End Date
January 1 2012
Last Update
January 31 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Austin Hospital
Heidelberg, Victoria, Australia, 3084