Status:
COMPLETED
Effect of Oligofructose on Appetite in Overweight Subjects
Lead Sponsor:
Imperial College London
Conditions:
Appetite Regulation
Obesity
Eligibility:
All Genders
20-50 years
Phase:
NA
Brief Summary
This study seeks to look into the effects of oligofructose supplementation on appetite, energy intake, and body weight and body composition in overweight subjects. Compared to a placebo product (cellu...
Detailed Description
Appetite regulation plays an important part in energy balance. Suppressing appetite by manipulating the diet is a safe way of reducing energy intake and body weight compared to drug therapy and obesit...
Eligibility Criteria
Inclusion
- Healthy males and females aged 20-50
- BMI 25-35 kg/m2
- Weight stable for three months prior to enrollment in study (weight change \< 3 kg over a period of three months)
- Habitual dietary fibre ≤ 25g/day (as assessed by 3-day dietary record)
- Non-smokers
- No current or history of endocrine disease, gastrointestinal disease, kidney or liver diseases, cardiovascular disease, pancreatitis, or cancer
- Hydrogen producers
Exclusion
- Use of antibiotic less than three months prior to participation in the study
- Participation in other research studies in the previous three months
- Blood donation less than three months before participation in study
- Anaemia
- Hypertension
- Pregnancy or breastfeeding
- Substance abuse
- Vegan diet
- Regular use of prebiotic, probiotic or symbiotic food items/ supplements
- Intense exercise undertaken for more than 5h per week
- Metallic or electronic implants e.g. pacemaker, cochlear ear implants, fixed dental braces
- Claustrophobia
- Depression
Key Trial Info
Start Date :
June 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2011
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT00912197
Start Date
June 1 2009
End Date
August 1 2011
Last Update
January 14 2021
Active Locations (1)
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1
Imperial College London, Hammersmith Hospital
London, United Kingdom, W12 0NN