Status:
UNKNOWN
Continuous Preperitoneal Infusion of Local Anesthetic (CPA) Versus Epidural Infusion of Local Anesthetic (EA) in Fast-Track Open Colorectal Surgery
Lead Sponsor:
University Hospital, Clermont-Ferrand
Conditions:
Open Colorectal Surgery
Early Rehabilitation After Surgery
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare the continuous preperitoneal infusion of local anesthetic and continuous epidural analgesia for postoperative pain management in fast-track open colorectal surg...
Detailed Description
Optimized pain relief allowing early mobilization is a prerequisite for enhanced recovery after surgery. Open colorectal surgery is associated with severe and prolonged postoperative pain, especially ...
Eligibility Criteria
Inclusion
- Age \> 18 years
- Open colorectal surgery through a midline incision with a primary anastomosis
- American Society of Anesthesiologists (ASA) physical status I to III
Exclusion
- Obesity (body mass index \> 35 kg/m2)
- Pregnancy
- Inflammatory bowel diseases
- Contraindication for epidural analgesia (patient refusal, active sepsis, coagulopathy)
- Chronic renal failure (with creatinin clearance \< 30 ml/min)
- Significant hepatic failure (prothrombin ratio \< 50%, factor V \< 50%)
- Chronic pain
- Preoperative opioid consumption
- Preoperative cognitive dysfunction
- Preoperative psychiatric disorders
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2018
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT00915265
Start Date
October 1 2009
End Date
October 1 2018
Last Update
January 31 2018
Active Locations (1)
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1
CHU Clermont-Ferrand
Clermont-Ferrand, France, 63003