Status:
TERMINATED
Topical IL-1-Ra for Treatment of Corneal Neovascularization
Lead Sponsor:
Reza Dana, MD
Conditions:
Corneal Neovascularization
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this study is to determine the effectiveness and safety of Interleukin-1-Receptor Antagonist eye drops for the treatment of corneal blood vessels.
Detailed Description
Normally avascular, under many pathologic conditions, vessels may invade the cornea from the limbal vascular plexus. Infection, inflammation, ischemia, degeneration, or trauma, and the loss of the lim...
Eligibility Criteria
Inclusion
- Ability to provide written informed consent and comply with study assessments for the full duration of the study
- Age \> 18 years
- Patients with superficial or deep corneal NV that extends farther than 1 mm from the limbus
- Patients are in generally good stable overall health
Exclusion
- • Has received treatment with anti-VEGF agents (topical, intraocular or systemic) within 30 days of study entry
- Corneal or ocular surface infection within 30 days prior to study entry• Ocular or periocular malignancy
- Contact lens (excluding bandage contact lens) use within 2 weeks prior to study entry
- Persistent epithelial defect (\>1mm and ≥14 days duration) within 2 weeks prior to study entry
- Intravitreal or periocular steroids within 2 weeks prior to study entry
- Change in dose/frequency of topical steroids and/or NSAIDs within 2 weeks prior to study entry
- Pregnancy (positive pregnancy test) or lactation
- Premenopausal women not using contraception
- Signs of current infection, including fever and current treatment with antibiotics
- Participation in another simultaneous medical investigation or trial
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2011
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00915590
Start Date
April 1 2009
End Date
March 1 2011
Last Update
May 8 2017
Active Locations (1)
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1
Massachusetts Eye and Ear Infirmary
Boston, Massachusetts, United States, 02114