Status:
COMPLETED
NPC Study : TAX + CIS Neoadjuvant in Patients With Loco Regionally Advanced Undifferentiated Carcinoma of Nasopharyngeal Type (UCNT)
Lead Sponsor:
Sanofi
Conditions:
Head and Neck Neoplasms
Eligibility:
All Genders
20-75 years
Phase:
PHASE2
Brief Summary
Primary Objective: To estimate the overall response rate after neo-adjuvant chemotherapy of Docetaxel 75 mg/m2 in combination with Cisplatin 75 mg/m2 given for 3 cycles, and followed by conventional ...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Written or witnessed oral informed consent prior to beginning specific protocol procedures \>Histologically proven undifferentiated carcinoma of nasopharyngeal type (UCNT- stage II-III OMS) at first diagnosis
- Staging of disease: stage III, IV A, IV B (UICC/AJCC, 1997 classification), any T, N2 - N3 UCNT, without metastasis
- Adenopathy \> 3 cm
- Patients are required to have an unidimensionally measurable disease with RECIST method
- Performance status 1 or karnofsky index 3
- Previous therapy: Chemotherapy :none Radiation therapy: none Surgery: none
- Laboratory requirements
- Exclusion criteria:
- Prior chemotherapy or / and radiotherapy
- Metastatic disease (M as per the UCCI/AJC classification)
- Past or current history of neoplasm other than UCNT, except for curatively treated non melanoma skin cancer or in situ carcinoma of the cervix or other cancer,curatively treated and with no evidence of disease at the previous 5 years
- Pregnant, or lacting, patients of childbearing potential must implement adequate contraceptive measures during study participation
- Pre-existing motor or sensory neurotoxicity of a severity 3 grade 2 according to NCI criteria
- Others serious illness or medical condition:
- Congestive heart failure or unstable angina pectoris even if it is medically controlled 2.Previous history of myocardial infraction within 1 year from study entry 3.Uncontrolled hypertension or high risk uncontrolled arrhythmias 4.Uncontrolled peptic ulcer, unstable diabetes mellitus susceptible to contraindicate any use of corticoids 5.Concomitant treatment with corticoids initiated \> 6 months prior to study entry is given to the dose of methylprednisolone or equivalent 3 20 mg 6.Definite contraindications for the use of Corticoids 7.Concurrent treatment with other experimental drugs 8.Participation in another clinical with any investigational drug within 30 days prior to study entry 9.Performance status = 2,3,4 or karnofsky index \< 80 10. History of significant neurologic or psychiatric disorders including psychotic disorders, dementia or seizures that would prohibit the understanding and giving of informed consent
- The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
Exclusion
Key Trial Info
Start Date :
July 1 2002
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2005
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT00916097
Start Date
July 1 2002
End Date
November 1 2005
Last Update
June 24 2009
Active Locations (3)
Enter a location and click search to find clinical trials sorted by distance.
1
Sanofi-Aventis Administrative Office
Algiers, Algeria
2
Sanofi-Aventis Administrative Office
Casablanca, Morocco
3
Sanofi-Aventis Administrative Office
Mégrine, Tunisia