Status:
COMPLETED
Measurement of Exhaled Nitric Oxide (NO) and Bronchial Provocation Test With Mannitol as a Predictor of Response to Inhaled Corticosteroids in Chronic Cough
Lead Sponsor:
Centre Hospitalier Universitaire de Saint Etienne
Collaborating Sponsors:
Syntara
Conditions:
Cough
Bronchial Hyperreactivity
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Chronic cough is defined by its persistence beyond 8 weeks. Many conditions can explain the existence of a bronchial inflammation. In the management of chronic cough, the search for bronchial hyperrea...
Detailed Description
The purpose of this study is to show that the use of the prospective value of exhaled NO can predict response to treatment with inhaled corticosteroids in adult with chronic cough. In addition we will...
Eligibility Criteria
Inclusion
- Chronic Cough during 2 months
- Social Security regimen affiliated
- Consent form signed
Exclusion
- Smoking active
- Treatment with angiotensin converting enzyme inhibitor
- Clinical signs of obvious gastroesophageal reflux
- Clinical rhinosinusitis
- Recent respiratory infection (\< 1 month)
- Corticosteroid Treatment(oral or inhaled) within 2 weeks
- VEMS \< 1 L or \< 80% of the theoretical value
- Existence of an obstructive ventilatory disorder defined as a report (FEV/FVC) \< 90% of the theoretical value
Key Trial Info
Start Date :
November 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2010
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00916526
Start Date
November 1 2008
End Date
September 1 2010
Last Update
November 24 2010
Active Locations (1)
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1
CHU de Saint-Etienne
Saint-Etienne, France, 42055