Status:
UNKNOWN
Diagnosis of Primary Aldosteronism: Comparison of Post Captopril Active Renin Concentration and Plasma Renin Activity
Lead Sponsor:
National Taiwan University Hospital
Collaborating Sponsors:
Novartis
Conditions:
Primary Aldosteronism
Eligibility:
All Genders
18-80 years
Brief Summary
Background: The most common pharmacologic test for diagnosis of primary aldosteronism (PA) is administration of captopril to examine whether abnormal aldosterone to plasma rennin activity (PRA)(ARR) p...
Detailed Description
Primary aldosteronism (PA), characterized by an inappropriate production of aldosterone, affects 5-13% of patients with hypertension(1, 2). The use of aldosterone-renin ratio (ARR) as screening test c...
Eligibility Criteria
Inclusion
- age at onset younger than 35 years,
- hypertension that is difficult to control after initiating therapy,
- clinical occurrence of a hypertensive crisis,
- the presence of hypokaliemia or metabolic alkalosis, or a random aldosterone-renin ration (ARR) \>30, and
- evidence of adrenal incidentaloma and hypertension or hypokalemia.
Exclusion
- chronic kidney disease with elevated estimated glomerular filtration rate (\< 60, mL/min/1.73 m2)
- liver disease with elevated GPT (\> 35)
- heart failure
- classified as more than NYHA II,
- hyperthyroidism
- malignancy with metastasis
Key Trial Info
Start Date :
January 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2009
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT00917345
Start Date
January 1 2008
End Date
May 1 2009
Last Update
June 10 2009
Active Locations (1)
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1
National Taiwan University Hospital
Taipei, Taiwan, 100