Status:
COMPLETED
Analysis of Blood-based Biomarkers of Asthma
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
Genentech, Inc.
Conditions:
Asthma
Eligibility:
All Genders
18-70 years
Brief Summary
The purpose of this study is to analyze markers of inflammation in blood and in induced sputum for the purpose of identifying molecular markers of specific asthma phenotypes. The investigators' specif...
Detailed Description
This is a cross-sectional study in patients with asthma and healthy controls in which we will analyze markers of inflammation in blood and in induced sputum for the purpose of identifying molecular ma...
Eligibility Criteria
Inclusion
- Asthmatic Subjects Inclusion criteria
- Male and female subjects between the ages of 18 and 70 years with a history of asthma who may or may not be taking inhaled corticosteroids for asthma control.
- Physician diagnosis of asthma
- PC20FEV1 methacholine ≤ 8.0 mg/mL, except for those taking daily inhaled corticosteroids, for which the PC20 methacholine should be \< 16 mg/mL.
- Ability to provide informed consent.
- Healthy Subjects Inclusion criteria
- Healthy male and female subjects with no history of asthma between the ages of 18 and 70 years. Subjects should not be taking inhaled or oral corticosteroids.
- No lifetime history of asthma or allergic rhinitis.
- Ability to provide informed consent.
- Exclusion Criteria for both subject groups
- Lung disease other than asthma.
- History of an upper or lower respiratory tract infection in the 4 weeks preceding the study.
- Females who are pregnant or breast-feeding
- Subjects must be non-smokers (patients who have never smoked or patients who have smoked ≤5 cigarettes per month and have a total pack-year smoking history \< 10 packs).
- Use of marijuana \>1 time per month in the last year and use of marijuana in the 6 weeks prior to enrollment
- Use of recreational drugs other than marijuana in the 12 months preceding the study.
- Use of Beta blocker medications
Exclusion
Key Trial Info
Start Date :
June 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2011
Estimated Enrollment :
127 Patients enrolled
Trial Details
Trial ID
NCT00917787
Start Date
June 1 2009
End Date
April 1 2011
Last Update
August 20 2020
Active Locations (1)
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1
UCSF Airway Clinical Research Center
San Francisco, California, United States, 94143-0130