Status:
UNKNOWN
Targeting Synovitis in Early Rheumatoid Arthritis
Lead Sponsor:
NHS Greater Glasgow and Clyde
Collaborating Sponsors:
University of Glasgow
Chief Scientist Office of the Scottish Government
Conditions:
Rheumatoid Arthritis
Polyarthritis
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Patients with rheumatoid arthritis are at risk of developing permanent joint damage and disability. This study hopes to identify the most effective way of using existing arthritis medication to minimi...
Detailed Description
PURPOSE 1 - to determine whether it is possible to achieve better control of inflammatory joint disease activity in early rheumatoid arthritis by using musculoskeletal ultrasound, instead of clinical ...
Eligibility Criteria
Inclusion
- Patients attending Early RA clinics with newly diagnosed RA or anti-CCP +ve Undifferentiated Arthritis (UA)
- Active disease (DAS28 \> 3.2)
- DMARD naïve or DMARD monotherapy for less than 6 weeks
- Aged 18 or more
Exclusion
- Significant liver disease and/or abnormality of liver function tests
- AST / ALT \> x2 normal, Alkaline Phosphatase \> x2.5 normal
- Renal impairment - serum creatinine \> 200 μmol/l, eGFR \< 30
- Cytopenias - white cell count \< 4.0, haemoglobin \< 10, platelet \< 150
- Pregnancy or planned pregnancy
- Contraindication to MRI
- Other co-morbid condition that in the opinion of the investigator would preclude the use of sequential or combination DMARD therapy
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2012
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT00920478
Start Date
September 1 2009
End Date
September 1 2012
Last Update
September 10 2009
Active Locations (3)
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1
Department of Rheumatology, Gartnavel General Hospital
Glasgow, United Kingdom, G12 0YN
2
Department of Rheumatology, Stobhill Hospital
Glasgow, United Kingdom, G21 3UW
3
Centre for Rheumatic Diseases, Glasgow Royal Infirmary
Glasgow, United Kingdom, G4 0SF