Status:
COMPLETED
Longitudinal Study in Perimenopausal Women With Risk Factors for Atherosclerosis
Lead Sponsor:
Ohio State University
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Atherosclerosis
Eligibility:
FEMALE
40+ years
Brief Summary
The study hypothesis (or theory) is that monthly loss of iron before menopause may reduce women's risk of hardening of the arteries, or atherosclerosis. This study uses noninvasive, noncontrast magne...
Detailed Description
Atherosclerosis, or hardening of the arteries, is the underlying disease responsible for the vast majority of cardiovascular morbidity and mortality and afflicted over 30 million Americans in 2005. Wh...
Eligibility Criteria
Inclusion
- women at least 40 yrs of age
- between 1 and 6 menstrual cycles in the past 12 months
- 2 or more of the following risk factors: high blood pressure, diabetes, high cholesterol, smoking
- no known heart or vascular disease
Exclusion
- any known cardiovascular disease such as coronary disease, peripheral vascular disease, heart failure
- contraindication to MRI scan (e.g. aneurysm clip, iron-containing metal)
- NOTE that orthopedic hardware is usually MRI-compatible. We will go over detailed screening before enrollment.
Key Trial Info
Start Date :
May 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2018
Estimated Enrollment :
177 Patients enrolled
Trial Details
Trial ID
NCT00921011
Start Date
May 1 2009
End Date
March 1 2018
Last Update
April 5 2018
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The Ohio State Univeristy Medical Center
Columbus, Ohio, United States, 43210