Status:
COMPLETED
Effect of Ibuprofen, Paracetamol and Their Combination on Radical Oxygen Species (ROS) Production
Lead Sponsor:
Ullevaal University Hospital
Collaborating Sponsors:
University of Oslo
Conditions:
Pain
Eligibility:
All Genders
18-35 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether paracetamol, ibuprofen or their combination can modify generation of radical oxygen species (ROS) from stimulated neutrophils.
Detailed Description
Non-steroidal anti-inflammatory drugs (NSAID) are used to alleviate clinical inflammatory symptoms (e.g. pain, swelling and reduced function). Leukocytes, upon activation during inflammatory states, g...
Eligibility Criteria
Inclusion
- Volunteers of both sexes (ASA type I).
- Females who are not pregnant or plan conception. (A pregnancy test will be conducted before each test day)
- Persons who have not used analgesics for 3 days prior to the blood sampling.
- Persons without known active peptic ulcer or gastrointestinal bleeding.
- Persons without any known hypersensitivity for NSAIDs.
- Persons under no other drug treatment than contraceptives.
- Age 18 to 35 years of Caucasian origin
Exclusion
- Pregnancy during the test period.
- Development of active peptic ulcer during the test period.
- Change in medication status during the test period (after inclusion).
Key Trial Info
Start Date :
May 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2010
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT00921505
Start Date
May 1 2009
End Date
January 1 2010
Last Update
July 6 2011
Active Locations (1)
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1
Ullevaal University Hospital
Oslo, Norway, NO-0407