Status:
COMPLETED
Stress Reactivity in Veterans Receiving Pharmacological Treatment for PTSD and Alcohol Dependence
Lead Sponsor:
Yale University
Conditions:
Post-traumatic Stress Disorder
Alcohol Dependence
Eligibility:
All Genders
21-65 years
Phase:
NA
Brief Summary
Method: This study is designed as an accompaniment to an already funded study - a 12-week treatment trial with prazosin for patients with PTSD and AD. The study design will consist of III phases. In ...
Detailed Description
Specific Aim: We propose a laboratory study that will examine stress reactivity as a marker for treatment response to prazosin in patients with PTSD and AD. Background: Increasing evidence shows that...
Eligibility Criteria
Inclusion
- male and female patients age 21 to 65.
- current diagnosis of DSM-IV PTSD (determined by SCID and CAPS and AD (determine by SCID)).
- participants who drink regularly (determined by TLFB and recorded 90 days prior to the interview), and are not abstinent for more than 2 weeks before participation in the study.
- are not in an active phase of alcohol withdrawal.
- are not at risk for suicide.
Exclusion
- current SCID diagnosis of any psychotic disorder.
- history of substance dependence (other than alcohol and nicotine) in the last 30 days.
- current unstable medical condition such as neurological, cardiovascular, endocrine, renal, liver, or thyroid pathology (LFT 5 times normal, abnormal BUN and creatinine, and unmanaged hypertension with BP \> 200/120) which in the opinion of the physician would preclude the patient from fully cooperating or be of potential harm during the course of the study.
- taking medication for a psychiatric condition.
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2015
Estimated Enrollment :
57 Patients enrolled
Trial Details
Trial ID
NCT00923923
Start Date
January 1 2009
End Date
July 1 2015
Last Update
December 14 2016
Active Locations (1)
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1
VA Connecticut Healtcase System
West Haven, Connecticut, United States, 06516