Status:
UNKNOWN
Comparing the Effects of Conivaptan and Diuretics on Plasma Neurohormones and Renal Blood Flow in Patients With Chronic Congestive Heart Failure
Lead Sponsor:
Hennepin County Medical Center, Minneapolis
Collaborating Sponsors:
Astellas Pharma Inc
Conditions:
Heart Failure
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The purpose of the study is to compare the effects of conivaptan and diuretics on renal blood flow and neurohormones.
Detailed Description
1. To define the hemodynamic, neurohormonal and renal responses to intravenous conivaptan in patients with chronic stable heart failure (HF), and compare these responses to those after intravenous fur...
Eligibility Criteria
Inclusion
- Have a diagnosis of chronic congestive heart failure of any etiology
- Be between 18-80 years of age
- Able to provide consent
- Have a documented left ventricular ejection fraction within the last year of \< 40%
- On a stable dose (no changes within 2 weeks) of 40 mg or greater daily dose of furosemide or its equivalent
- On standard HF therapy medications (ACEI or ARB and beta-blocker unless contraindicated)
- Have an estimated glomerular filtration rate (GFR) of 30 ml/minute or greater (based on the Cockcroft Gault calculation)
- Have a hemoglobin of \> 10 grams/dl
- Have a negative urine pregnancy for women of childbearing years only
Exclusion
- Acute coronary syndrome within 1 month
- Systolic blood pressure less than or equal to 90 mmHg at time of enrollment
- Poor peripheral venous access
- Severe concomitant disease which deemed by the investigator would render them unsuitable for this trial
- Allergy or contraindication to the use of iothalamate, PAH - Specifically any allergies to iodine or iodine containing products, history of asthma and hay fever which deemed by the investigator would render them unsuitable for this trial
Key Trial Info
Start Date :
July 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2010
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT00924014
Start Date
July 1 2009
End Date
March 1 2010
Last Update
June 18 2009
Active Locations (1)
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1
Hennepin county Medical Center
Minneapolis, Minnesota, United States, 55404