Status:
COMPLETED
Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass
Lead Sponsor:
University of Zurich
Conditions:
Cardiac On-pump Surgery
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
Organ protection, volatile anesthetics, postconditioning. Sedation of patients on ICU after cardiac surgery with cardiopulmonary bypass with either propofol or sevoflurane. Evaluation of organ functi...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- CABG and/or heart valve surgery with CPB
- Ejection fraction (EF) = 30%
- Canadian Cardiovascular Society (CCS) classification = 3
- Ages 18 to 90 years old
- Exclusion criteria:
- Pulmonary disease: forced expiratory volume in one second (FEV1) \< 80%; FEV1/forced vital capacity (FVC) \< 70%
- Renal disease and/ or creatinine-clearance \< 60 ml/min
- Previous cardiac surgery
- Emergency procedures
- Postoperative intra aortic balloon pump (IABP) requirement
- Myocardial infarction \< 7d
- Steroid treatment
- Insulin-dependent diabetes
- Pregnancy
Exclusion
Key Trial Info
Start Date :
October 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00924222
Start Date
October 1 2007
End Date
December 1 2009
Last Update
October 12 2011
Active Locations (1)
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1
Zurich, Switzerland