Status:
COMPLETED
Grains Reduce Adiposity and Improve Nutrition Study
Lead Sponsor:
Penn State University
Collaborating Sponsors:
General Mills
Conditions:
Metabolic Syndrome
Insulin Resistance
Eligibility:
All Genders
35-55 years
Phase:
NA
Brief Summary
Whole grain intake beneficially affects body weight, body fat and glucose metabolism, and the investigators' previous work has shown that a high whole grain intake significantly reduced body fat in th...
Detailed Description
Including whole grains as part of a heart-healthy diet has been shown to be beneficial in decreasing body weight and body fat. The beneficial effects of whole grains on body weight may be explained by...
Eligibility Criteria
Inclusion
- BMI \> 25 to \< 42
- Waist circumference of \> 40 inches for males and \> 35 inches for females and having one other of the criteria for metabolic syndrome will be recruited
- In this population, we will also accept the following:
- LDL-C \< 175 mg/dL
- HDL-C \> 25 mg/dL
- Triglycerides \< 400 mg/dL
- All subjects will be required to meet one specific criteria for metabolic syndrome beyond increased waist circumference
Exclusion
- Smokers
- Have insulin-dependent diabetes
- Are pregnant or expecting to be pregnant, lactating in the last 6 months
- Are taking NSAIDS or other medications known to affect inflammatory markers or drugs affecting glucose metabolism
- Blood pressure lowering medications are acceptable if the person has controlled BP at screening, \<140/90 mmHg.
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2011
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT00924521
Start Date
March 1 2009
End Date
August 1 2011
Last Update
August 21 2023
Active Locations (1)
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1
Penn State University
University Park, Pennsylvania, United States, 16802