Status:
UNKNOWN
The Role of the Glutamatergic System in the Extinction of Conditioned Reinforcement Processes
Lead Sponsor:
Central Institute of Mental Health, Mannheim
Collaborating Sponsors:
German Research Foundation
Conditions:
Alcohol Drinking
Eligibility:
All Genders
18-65 years
Phase:
PHASE2
PHASE3
Brief Summary
The aim of this project is to explore whether the extinction of cue-reactivity following a cue-exposure based intervention in volunteers with an alcohol dependence is facilitated by drugs that increas...
Eligibility Criteria
Inclusion
- current DSM-IV/ ICD-10 diagnosis of alcohol dependence
- controlled abstinence for a period of 5 to 21 days following admission to inpatient detoxification or day-clinic care
- women (in childbearing age): use of a highly effective method of contraception
- normal or corrected-to-normal vision
- ability to provide written informed consent
Exclusion
- diagnosis of additional axis I or II disorders (according to DSM-IV( ICD- 10 criteria) either currently or within the past 12 months (except nicotine dependence)
- positive drug screening
- current medication with anti-convulsive or psychotropic drugs
- MRI ineligibility
- sensitivity to study medication as evidenced by a history of adverse drug experience
- severe withdrawal symptoms (e.g. convulsions, delirium)
- disposition towards experiencing convulsions/ epilepsy
- history of schizophrenic disorders/ affective psychosis
- neurological diseases that might affect the dopaminergic, limbic and frontal cortices or extrapyramidal motor functioning
- major diseases (e.g. diabetes, liver cirrhosis, heart disease)
- physical illness interfering with study procedures or affecting study outcomes
- pregnancy (positive test results)/ lactation period
- suicidal tendencies/ increased risk that others might be harmed -
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00926900
Start Date
March 1 2009
Last Update
November 28 2011
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Central Institute of Mental Health
Mannheim, Germany, 68159