Status:
COMPLETED
Continuous Positive Airway Pressure and Acetazolamide to Treat Sleep Apnea Syndrome Patients at Altitude
Lead Sponsor:
University of Zurich
Conditions:
Obstructive Sleep Apnea Syndrome
Eligibility:
All Genders
20-80 years
Phase:
PHASE4
Brief Summary
The purpose of the study is to investigate the effect of nasal continuous positive airway pressure in combination with acetazolamide as a treatment for sleep related breathing disturbances in patients...
Eligibility Criteria
Inclusion
- Obstructive sleep apnea syndrome, successfully on CPAP therapy
- Residence at low altitude (\< 800 m)
- Obstructive apnea/hypopnea index \>20/h and a complaint of excessive daytime sleepiness before introduction of CPAP therapy
- \> 15 oxygen desaturations/h (\> 3% dips) during an ambulatory nocturnal pulse oximetry performed at the end of a 4-night period without CPAP
Exclusion
- Sleep disorders other than OSA
- More than mild cardiovascular disease, unstable cardiovascular disease
- Any lung disease, pulmonary hypertension
- Chronic rhinitis
- Treatment with drugs that affect respiratory center drive (benzodiazepines or other sedatives or sleep inducing drugs, morphine or codeine derivates), stimulants (modafinil, methylphenidate, theophylline)
- Internal, neurologic or psychiatric disease that interfere with sleep quality
- Previous intolerance to moderate or low altitude (\< 2600 m)
- Exposure to altitudes \> 1500m for \> 1 day within the last 4 weeks before the study
Key Trial Info
Start Date :
June 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2009
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT00928655
Start Date
June 1 2009
End Date
November 1 2009
Last Update
May 20 2014
Active Locations (1)
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1
University Hospital of Zurich, Pulmonary Division and Sleep Disorders Centre
Zurich, Switzerland, CH-8091