Status:
COMPLETED
Effect of Rosuvastatin Therapy in Patients With Stable Chronic Obstructive Pulmonary Disease
Lead Sponsor:
University Hospital, Akershus
Collaborating Sponsors:
AstraZeneca
Haukeland University Hospital
Conditions:
Chronic Obstructive Pulmonary Disease (COPD)
Eligibility:
All Genders
40-80 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to investigate whether rosuvastatin improves measures of endothelial function, decreases measures of inflammation, and improves pulmonary function in patients with stable ...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Stable COPD patients of both genders with no COPD exacerbations less than three weeks prior to inclusion
- COPD stage I to IV after the GOLD criteria (Global Initiative for Chronic Obstructive Lung Disease)
- Age between 40 and 80 years
- Exclusion criteria:
- Diagnosed lung disease other than COPD, except chronic asthmatic bronchitis and mild bronchiectasis without or few physical signs (diagnosed by high resolution CT)
- History of or active coronary artery disease (CAD), cerebrovascular or peripheral vascular disease
- History of or clinically significant congestive heart failure, valvular heart disease, clinically significant arrhythmias or conduction delays
- History of uncontrolled arterial hypertension (defined as blood pressure above180/110 mmHg with or without the use of antihypertensive medication)
- Body mass index \>40kg/m2
- History of diabetes mellitus, measured fasting glucose \> 11 mmol/L
- History of Hypercholesterolemia, measured total cholesterol \> 8 mmol/L
- Known poliomyelitis, motor neurone disease, cranial or temporal arteritis, stroke or myopathy
- Neutropenia, anemia (Hb \< 8 g/100mL)
- History of chronic renal failure, serum creatinine \> 176 micromol/L (2.0mg/dL)
- Creatine kinase \> 3 times the upper limit of normal (ULN)
- Acute or chronic liver disease (serum transaminases \> 3 times the ULN)
- Pregnancy (oral examination and blood test prior to inclusion)
- Active abuse of drugs or alcohol, poor compliance anticipated
- Statin use within the last 4 weeks prior to study start or previously clear indication for statin use
- Prior diagnosis of statin induced myopathy or hypersensitivity reaction to another hydroxymethylglutaryl-Coenzyme A-reductase inhibitor incl. Rosuvastatin
- History of malignant disease of any kind within 5 years prior to inclusion.
- History of uncontrolled hypothyroidism
- Participation in another pharmaceutical or medical device clinical trial study less than 4 weeks prior inclusion.
- Use concomitant of medications that are known to interact with Crestor. This includes the following medications: Warfarin and other coumarin (vitamin K antagonist) anticoagulants, Cyclosporin, Gemfibrozil and Antacid
Exclusion
Key Trial Info
Start Date :
March 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2014
Estimated Enrollment :
99 Patients enrolled
Trial Details
Trial ID
NCT00929734
Start Date
March 1 2010
End Date
January 1 2014
Last Update
October 8 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Akershus University Hospital
Lørenskog, Akershus, Norway, 1478