Status:
TERMINATED
Safety Study of Cervical Sympathetic Block for Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage
Lead Sponsor:
University of Washington
Conditions:
Vasospasm
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
To evaluate the feasibility of performing a cervical sympathetic block in patients with severe cerebral vasospasm involving the anterior cerebral circulation following aneurysmal SAH.
Eligibility Criteria
Inclusion
- High grade spontaneous SAH (Fisher Grade III and IV)
- Secured aneurysm (clipped/coiled)
- Evidence of severe vasospasm - MCA mean flow velocity \>200 cm/sec and Lindegaard ratio \>6 OR Symptomatic vasospasm with either angiographic evidence (no angioplasty), or at least moderate severity according to TCD criteria (MCA mean flow velocity \>150 cm/sec and Lindegaard ratio \>3, or ACA vasospasm)
- Age ≥18
Exclusion
- Allergy to local anesthetic or contrast
- Coagulation disorders with PT \<70%, or INR \>1.4, or PTT \>1.5 times control and/or platelets \<70,000x106/L
- Use of enoxaparin within 12 hours
- Use of clopidogrel within 7 days
- Use of coumadin within 5 days
- Use of ticlopidine within 14 days
- Use of intravenous thrombolytics within 10 days
- Any use of hirudin derivatives during ICU stay
Key Trial Info
Start Date :
April 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
7 Patients enrolled
Trial Details
Trial ID
NCT00930072
Start Date
April 1 2009
End Date
December 1 2014
Last Update
September 27 2017
Active Locations (1)
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1
Harborview Medical Center
Seattle, Washington, United States, 98104