Status:
COMPLETED
Ruminant Trans Fats and the Risk of Cardiovascular Disease in Women
Lead Sponsor:
Laval University
Collaborating Sponsors:
Institute of Nutraceuticals and Functional Foods
Dairy Farmers of Canada
Conditions:
Cardiovascular Disease
Eligibility:
FEMALE
18-70 years
Phase:
NA
Brief Summary
While the deleterious effects of trans fat from industrial sources (iTFA) on cardiovascular health are well established, the impact of TFA from ruminants (rTFA) on cardiovascular risk factors has not ...
Detailed Description
Ruminant trans fatty acids (rTFA) will come from an experimental butter formulated from dairy fat obtained after having modified the regimen of lactating cows. All diets will be identical in terms of ...
Eligibility Criteria
Inclusion
- Healthy women using or not contraceptive agents or hormone supplementation
- For pre-menopausal women: regular menstrual cycle for the last 3 months (25- 35 days)
- LDL-Cholesterol concentration between 2.5 and 4.0 mmol/L
- Stable body weight (+/- 2 kg) for 6 months before the beginning of the study
- Smoking or not
Exclusion
- Previous history of cardiovascular disease, type 2 diabetes and monogenic dyslipidemia
- Subjects taking medications for hyperlipidemia or hypertension
- Endocrine disorders
- Body mass index \> 35 kg/m2
- Food allergies
- Women with extreme nutritional habits such as vegetarism or alcohol consumption \> 2 drinks/day
- Elite athletes
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2011
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT00930137
Start Date
September 1 2009
End Date
September 1 2011
Last Update
March 5 2013
Active Locations (1)
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1
Institute of Nutraceutical and Functional Foods (INAF), Laval University
Québec, Quebec, Canada, G1V 0A6