Status:
COMPLETED
Preventing Recurrent Vascular Events in Patients With Stroke or Transient Ischemic Attack
Lead Sponsor:
University of Alberta
Collaborating Sponsors:
Heart and Stroke Foundation of Canada
Alberta Heritage Foundation for Medical Research
Conditions:
Ischemic Stroke
Transient Ischemic Attacks
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
People who have had a stroke or transient ischemic attack (TIA or "mini-stroke") are at high risk of having another stroke or a heart attack. Conditions like high blood pressure and high cholesterol, ...
Detailed Description
BACKGROUND: Epidemiological studies have shown that a number of conditions increase the risk of stroke and other vascular diseases and there is compelling evidence from large randomized trials that tr...
Eligibility Criteria
Inclusion
- A stroke specialist-determined ischemic stroke or TIA within the past year (including ocular strokes/TIA such as amaurosis fugax).
- Presence of systemic hypertension (average systolic blood pressure over two visits - i.e., SPC visit and study screening visit- exceeding 140 mmHg) OR fasting LDL cholesterol exceeding 2.0 mmol/L OR total: HDL cholesterol ratio exceeding 4.0 at SPC visit.
Exclusion
- Neurological event considered to be due to intracranial hemorrhage (e.g., ICH, SAH), or trauma induced, or related to structural heart disease such as ASD/VSD or endocarditis.
- Foreshortened life-expectancy (e.g., active malignancy), hypertensive crisis (clinic systolic BP \> 200 mm Hg), or severe comorbidities.
- Institutionalized in a long-term care facility.
- Cognitive impairment (defined as a score of \> 5 on the Short Portable Mental Status questionnaire).
- Already on maximal therapy for risk factors (on 3 antihypertensive drugs at maximal dose if hypertension is inclusion criterion or on maximal dose statin if hyperlipidemia is inclusion criterion).
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2013
Estimated Enrollment :
279 Patients enrolled
Trial Details
Trial ID
NCT00931788
Start Date
January 1 2009
End Date
November 1 2013
Last Update
October 15 2018
Active Locations (1)
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1
University of Alberta Hospital
Edmonton, Alberta, Canada, T6G 2B7