Status:
COMPLETED
Cotrimoxazole Versus Amoxicillin in the Treatment of Community Acquired Pneumonia in Children Aged 2-59 Months
Lead Sponsor:
Makerere University
Conditions:
Childhood Pneumonia
Eligibility:
All Genders
2-59 years
Phase:
PHASE3
Brief Summary
The investigators hypothesized that Oral amoxicillin (25mg/kg/dose bid) given to children aged 2-59 months with pneumonia, would lead to better clinical outcome on day three in 89.9% of the children c...
Detailed Description
A triage Nurse identified and recorded children aged 2- 59 months who presented with a history of cough, difficult breathing, or fast breathing (tachypnea) in the Assessment Center of Mulago Hospital....
Eligibility Criteria
Inclusion
- Children aged 2-59 months with non severe pneumonia based on WHO criteria of respiratory rate above the age specific cut-off
- Accessible to follow up
- Written informed consent from the parent/caretaker
Exclusion
- Children with severe pneumonia
- Documented use of antibiotics for the last 48 hours
- Confirmed HIV positive on cotrimoxazole prophylaxis
- Three or more episodes of wheezing in a year with asthmatic attack
- History of hospitalization within last 15 days
- Measles within last one month
- Previous history of allergy to cotrimoxazole or amoxicillin
Key Trial Info
Start Date :
July 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2008
Estimated Enrollment :
505 Patients enrolled
Trial Details
Trial ID
NCT00933049
Start Date
July 1 2007
End Date
January 1 2008
Last Update
July 7 2009
Active Locations (1)
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1
Faculty of Medicine, Makerere University
Kampala, Uganda