Status:
COMPLETED
Vascular Inflammation in Adolescents With Type 1 Diabetes
Lead Sponsor:
Children's Mercy Hospital Kansas City
Conditions:
Type 1 Diabetes Mellitus
Coronary Artery Disease
Eligibility:
All Genders
12-18 years
Brief Summary
The purpose of this study is to find out if diabetes damages the blood vessels of adolescents with good diabetes control compared to adolescents with less optimal control.
Detailed Description
Many published studies reveal that adult patients with T1DM can have early, silent and more advanced vessel wall thickness than normal subjects. This is influenced by the degree of their blood sugar c...
Eligibility Criteria
Inclusion
- Adolescents ages 12-18 years
- Tanner stage III-V
- T1DM \> 2 years
- HgbA1c \<8 or \>10 for previous 2 years
Exclusion
- Subjects with known history of hypercholesterolemia or family history of hypercholesterolemia
- Family history of premature cardiovascular disease
- Hypertension defined as subjects with blood pressure greater than the 90th percentile for age
- Anemia defined as Hgb \<11.0 g/dl
- ADHD
- Congenital heart disease
- Pituitary tumor
- Known allergy to ultrasound gel
- Recent head injury
- Chromosomal abnormalities
Key Trial Info
Start Date :
January 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT00933101
Start Date
January 1 2010
End Date
June 1 2011
Last Update
June 27 2011
Active Locations (1)
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1
Children's Mercy Hospitals and Clinics
Kansas City, Missouri, United States, 64108