Status:
TERMINATED
Functional Imaging of Tumor and Normal Tissue
Lead Sponsor:
Duke University
Conditions:
Head and Neck Cancer
Eligibility:
All Genders
18-80 years
Brief Summary
Dynamic contrast-enhanced (DCE) - magnetic resonance imaging (MRI), diffusion-weighted (DW)-MRI, and fludeoxyglucose - positron emission tomography - computed tomography (FDG-PET-CT) are three modalit...
Detailed Description
Patients will undergo functional imaging studies, DCE-MRI pre-treatment (twice) and after 1 week of Radiation Therapy (RT) and PET scans - pre-treatment and after 1 week of RT. Parotid gland saliva pr...
Eligibility Criteria
Inclusion
- Histologically documented squamous cell carcinoma of the head and neck (AJCC stages II-IV, M0)
- Eligible anatomic sites: Oral cavity, oropharynx, hypopharynx, supraglottic and glottic larynx, or nasopharynx
- Curative intent concurrent chemoradiation
- Age \> 18 years
- Karnofsky Performance Status \> 60
- Able to undergo MRI with contrast (gadolinium) and/or FDG PET scan
Exclusion
- Diabetes other than diet controlled
- MRI Absolute Contraindications including:
- Glomerular filtration rate \< 60 ml/min
- Weight \< 350 lb or current device limitations
- Metallic foreign bodies in the eye
- Cardiac pacemakers
- Clips in the central nervous system (ferromagnetic haemostatic)
- Automatic internal cardiac defibrillators
- Cochlear implants
- Shrapnel in vital locations
- Pregnant (positive pregnancy test) or lactating
Key Trial Info
Start Date :
October 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2011
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT00933114
Start Date
October 1 2009
End Date
September 1 2011
Last Update
April 11 2012
Active Locations (1)
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1
Duke University Medical Center, Department of Radiation Oncology
Durham, North Carolina, United States, 27710