Status:
TERMINATED
Trial to Assess the Effects of Different Trans-fatty Acids on Endothelial Function in Humans
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Collaborating Sponsors:
Agroscope Liebefeld-Posieux Research Station ALP
University of Bern
Conditions:
Healthy
Eligibility:
All Genders
45-69 years
Phase:
NA
Brief Summary
The aim of the study is to compare a diet rich in trans fatty acids (TFA) from ruminant sources with a diet rich in TFA from hydrogenated vegetable oils (PHVO) in regard to their effects on cardiovasc...
Detailed Description
Background: For some time already negative effects of trans fatty acids (TFA) on the cardiovascular system are known. The main TFA sources in our nutrition are partly hydrogenated vegetable oils (PHV...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- age 45-69
- body mass index 20-30 kg/m2
- willingness to hold physical activity constant over study duration
- written informed consent
- Exclusion Criteria
- smoking
- hypertension (\> 140/90 mm Hg)
- hypotension (men \< 115 mm Hg; women \< 105 mm Hg)
- obesity (BMI =/\> 30 kg/m2)
- vegan
- infections in the last 6 weeks
- allergy for food (e.g., milk)
- pregnancy
- diabetes (elevated fasting blood glucose level)
- clinical known coronary diseases
- acute and/or chronical medication (incl. contraceptive)
- abnormal kidney function
- abnormal liver function
- known cardiac arrhythmia (e.g., atrial fibrillation)
- blood parameters (ALAT, Creatinin, Hb, potassium, CRP) in range
Exclusion
Key Trial Info
Start Date :
July 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2013
Estimated Enrollment :
142 Patients enrolled
Trial Details
Trial ID
NCT00933322
Start Date
July 1 2009
End Date
June 1 2013
Last Update
July 12 2013
Active Locations (1)
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1
Cardiovascular Prevention and Rehabilitation, Bern University Hospital
Bern, Canton of Bern, Switzerland, 3010