Status:
COMPLETED
Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections
Lead Sponsor:
Federal University of Minas Gerais
Collaborating Sponsors:
Fundação de Amparo à Pesquisa do estado de Minas Gerais
Conditions:
Severe Sepsis
Septic Shock
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In this study the investigators aim to test if C-reactive protein (CRP)or procalcitonin(PCT) - guided strategy allows to reduce the antibiotic use in patients wiht severe sepsis and septic shock. Ther...
Detailed Description
Methods * Patients and settings: Prospective controlled randomized open interventional study of antibiotic therapy in adult with severe sepsis or septic shock, admitted to the intensive care unit. T...
Eligibility Criteria
Inclusion
- age \> 17 years
- patients in intensive care unit
- signed informed consent
- suspected or confirmed severe sepsis or septic shock
Exclusion
- Infections caused by Listeria spp, Legionella pneumophilia, Mycobacterium tuberculosis
- Bacteremia due S. aureus
- Infections requiring prolonged therapies, such as endocarditis, cerebral abscess, chronic osteomyelitis
- Suspected or confirmed infection caused by virus, parasites
- Infections caused by P. aeruginosa ou A. baumannii
- Severe immunosuppression (ex: AIDS, post bone-marrow transplant,cystic fibrosis)
- Traumatism latest five days
- Surgery latest 5 days
- Carcinoid tumor, lung cancer, medullary thyroid cancer
Key Trial Info
Start Date :
September 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2012
Estimated Enrollment :
94 Patients enrolled
Trial Details
Trial ID
NCT00934011
Start Date
September 1 2009
End Date
May 1 2012
Last Update
February 3 2016
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Hospital das Clínicas - Universidade Federal de Minas Gerais
Belo Horizonte, Minas Gerais, Brazil