Status:
WITHDRAWN
Interplay Between Organic Anion Transporting Polypeptide (OATP) Transporters Transporters and CYP2C9 in Glyburide Pharmacokinetics (PK)
Lead Sponsor:
University of California, San Francisco
Conditions:
Healthy
Eligibility:
All Genders
18-60 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to investigate if the drugs rifampin and fluconazole when given together increase the concentrations in the body of the oral diabetes medication glyburide.
Detailed Description
The purpose of this study is to find out if a drug interaction occurs when glyburide is taken with rifampin and fluconazole. Glyburide is an oral drug commonly used to lower blood glucose levels in di...
Eligibility Criteria
Inclusion
- Healthy adult with no active medical problems or significant chronic diseases as determined by the study doctor based on history, physical exam and laboratory evaluations;
- BMI between 18.5 - 30 kg/m2;
- Taking no medications 2 weeks before and during the study enrollment, including drugs of abuse, prescription or OTC medications (except acetaminophen);
- Subjects must be able to maintain adequate birth control during the study independent of hormonal contraceptive use;
- Be able to provide written informed consent and comply with requirements of the study;
- Avoid eating grapefruit and drinking grapefruit juice from 7 days before the first study day until completion of the entire study;
- Abstinence from alcoholic beverages, caffeinated beverages and orange juice from 6pm the night before a study day until completion of that study day;
- Fast from food and beverages at least 8 hours prior to medication dosing;
- Be able to read, speak and understand English
Exclusion
- Subjects on prescription or chronic over-the counter medications (including hormonal contraceptives);
- Subjects with known allergy to glyburide and/or rifampin and/or fluconazole;
- Subjects who are not homozygous for CYP2C9 \*1 (known poor metabolizers);
- Subjects with liver failure or LFTs \>2x upper limit of normal;
- Subjects with clinically significant elevations in SCr, BUN or other screening laboratory tests as determined by study physician;
- Subjects with Hct \<30 mg/dL;
- Subjects who smoke tobacco;
- Subjects with ongoing alcohol or illegal drug use;
- Subjects who are pregnant, lactating or attempting to conceive;
- Subjects unable to maintain adequate birth control during the study;
- Subjects unable to follow protocol instructions or protocol criteria.
Key Trial Info
Start Date :
February 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2010
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00935363
Start Date
February 1 2010
End Date
April 1 2010
Last Update
January 14 2015
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