Status:
COMPLETED
High Tidal Volume Induces Inflammation In Normal Lungs
Lead Sponsor:
Federal University of Rio Grande do Sul
Collaborating Sponsors:
Programa de Pós-Graduação em Clínica Médica
Faculdade de Medicina
Conditions:
Mechanically Ventilated Patients
Normal Lungs
Eligibility:
All Genders
16+ years
Phase:
NA
Brief Summary
Objective: To compare the effects of a protective versus a conventional ventilatory strategy, on systemic and in lung production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) in ...
Eligibility Criteria
Inclusion
- age ≥ 16 years;
- anticipated survival \> 24 hours;
- need for mechanical ventilation for at least 12 hours and
- hemodynamic stability (MAP\>65 mmHg, HR\<100 beats/min, diuresis \> 1 ml/kg/h, no catecholamine requirement or fluid challenge).
Exclusion
- 1\. history of any lung disease, use of immunosuppressive medication, recent infections, previous thromboembolic disease, recent ventilatory support, and participation in another clinical trial. Absence of lung disease was defined by the following clinical criteria: (a) no evidence of respiratory infection (white blood cell count \<10x103/µl, temperature \> 380C, purulent sputum), (b) normal chest roentgenogram, (c) PaO2/FIO2 ratio \> 300, (d) and a normal clinical respiratory history.
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00935896
Last Update
July 9 2009
Active Locations (2)
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1
Complexo Hospitalar Santa Casa
Porto Alegre, Rio Grande do Sul, Brazil, 900000
2
Hospital de Pronto Socorro
Porto Alegre, Rio Grande do Sul, Brazil, 90000