Status:
WITHDRAWN
Effect of Diuretics on Fluid Status Control and Residual Renal Function in Peritoneal Dialysis Patients
Lead Sponsor:
Sun Yat-sen University
Conditions:
Renal Function Disorder
Eligibility:
All Genders
20-70 years
Phase:
PHASE3
Brief Summary
A prospective, randomized, open-label, stratified, controlled clinical trial to evaluate whether long term furosemide therapy (1 year) would preserve urine volume and/or residual renal function (RRF) ...
Detailed Description
There are 3 phases in this study. Phase 1 is screening phase. Each subject will be evaluated to determine if he/she is eligible for the study. Phase 2 is the intervention phage. Patients are divided a...
Eligibility Criteria
Inclusion
- Willingness to sign an informed consent
- Age:20\~70 years, regardless of gender
- All patients received CAPD more than 1 months;
- Urine volume of 500ml/d or more;
- No history of taking furosemide for at least 2 weeks .
Exclusion
- Inability or unwillingness to sign the informed consent
- Inability or unwillingness to meet the scheme demands raised by the investigators
- Current acute infection such as peritonitis ;
- Severe diarrhea or vomiting within the preceding 1 month
- Acute Cardiac failure
- Myocardial infarction within the preceding 6 months;
- Hypertensive encephalopathy or cerebrovascular accident;
- Accident within the preceding 6 months;
- Any condition, such as alcohol or drug abuse, chronic liver disease, malignant disease, or psychiatric disorder;
- Allergy or intolerance to furosemide .
- Current or recent (within 2 weeks) exposure to any other investigational drugs
Key Trial Info
Start Date :
June 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00936923
Start Date
June 1 2008
End Date
December 1 2012
Last Update
May 21 2015
Active Locations (1)
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1
The 1st Affiliated Hospital, Sun Yet-sen University
Guangzhou, Guangdong, China, 510080