Status:
COMPLETED
Effect of Epidural Steroid Injection on Bone Mineral Density in Postmenopausal Women
Lead Sponsor:
Henry Ford Health System
Conditions:
To Assess the Changes in Markers of Bone Turnover Over a Six Month Period After Epidural Steroid Inject
To Assess the Changes in Bone Mineral Density
Eligibility:
FEMALE
55-80 years
Phase:
PHASE4
Brief Summary
To evaluate for the effect of corticosteroid epidural injections on bone mineral density in postmenopausal women. Candidates for the study: Post menopausal women between the ages of 55 and 80. No hist...
Detailed Description
Glucocorticoids reduce bone formation and increase bone loss via a variety of mechanisms. This effect has been shown to be dose-dependent. Doses as low as 10mg of Prednisone, has been shown to lower b...
Eligibility Criteria
Inclusion
- Patients with low back pain and have consented to ESI. Age 55 and 5 years postmenopausal Caucasian women.
Exclusion
- any women who doesn't meet the inclusion criteria
- Women with history of a disease affection bone turnover
- Women taking any drugs known to influence bone metabolism
- Women who had smoked within the preceding year
- Women with abnormal serum thyrotropin concentration, or high parathyroid hormone concentratons.
- Women who had received more than two short courses (lasting 2 weeks or less) of oral or parenteral glucocorticoids in the preceding year or any oral or pareneteral or local (intraarticular, paraspinal,...) or inhaled glucocorticoids in the preceding year
- Women diagnosed with osteoporosis (T score\<=2.5) on baseline DXA or had history of osteoportic fracture.
- Pregnant women
- Severe scoliosis -
Key Trial Info
Start Date :
July 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2011
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT00941473
Start Date
July 1 2007
End Date
July 1 2011
Last Update
February 20 2024
Active Locations (1)
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1
Henry Ford Hospital W. Bloomfield
West Bloomfield, Michigan, United States, 48322