Status:
COMPLETED
The Effect of Fish Oils on Human Hepatic Colorectal Metastases
Lead Sponsor:
University Hospitals, Leicester
Collaborating Sponsors:
B. Braun Melsungen AG
Conditions:
Colorectal Liver Metastases
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine whether fish oils - a known source of omega-3 given intravenously (via a 'drip') will help cure secondary deposits in the liver from bowel cancer.
Detailed Description
Fish oils have many proven benefits for a wide range of clinical arenas such as ischaemic heart disease, rheumatoid arthritis and inflammatory bowel disease. Recent research has described the benefic...
Eligibility Criteria
Inclusion
- Aged 18-80
- Able to give informed written consent
- Diagnosis of respectable hepatic colorectal metastases on radiological and laparoscopic appearances
Exclusion
- Patients already taking fish oil supplements
- Hypersensitivity to fish-, egg-, or soy protein, or to any of the active substances or constituents in the lipid emulsion
- Hyperlipidaemia
- Severe blood coagulation disorders
- Severe renal insufficiency (Creatinine \>200)
- Any general contra-indications to infusion therapy - pulmonary oedema, hyperhydration, decompensated cardiac insufficiency
- Any unstable medical conditions - uncontrolled diabetes mellitus, acute myocardial infarction, stroke, embolic disease, metabolic acidosis, sepsis, pancreatitis
- Patients undergoing conventional neo-adjuvant chemotherapy.
Key Trial Info
Start Date :
May 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2010
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT00942292
Start Date
May 1 2007
End Date
October 1 2010
Last Update
June 25 2013
Active Locations (1)
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1
Leicester General Hospital
Leicester, Leicestershire, United Kingdom, LE5 4PW