Status:
COMPLETED
Adjuvant Analgesic Effects of Low Dose Tramadol/Acetaminophen Combination After Open Gynaecological Surgery
Lead Sponsor:
The University of Hong Kong
Conditions:
Postoperative Pain
Eligibility:
FEMALE
18-80 years
Phase:
PHASE4
Brief Summary
Patient experience moderate to severe pain after abdominal surgery. This post-operative pain can also contribute to complications such as respiratory impairment, cardiovascular events, ileus, sleep de...
Detailed Description
This is a randomized, double-blinded, placebo-controlled study. Study site Patients will be recruited and studied at Queen Mary Hospital, Hong Kong. Anaesthesia for operation No premedication will b...
Eligibility Criteria
Inclusion
- ASA I to III
- Age 18 to 80 years
- Scheduled for elective lower abdominal surgery (gynecological or colorectal surgery) at Queen Mary Hospital, Hong Kong
Exclusion
- Allergy to tramadol, acetaminophen, or other opioid drugs
- Patient with epilepsy or history of seizures
- Concurrent use of selective serotonin uptake inhibitors, tricyclic antidepressants, or monoamine oxidase inhibitors
- Impaired or retarded mental state
- Impaired renal function, defined as preoperative serum creatinine level over 120µmol/L
- Impaired hepatic function, defined as preoperative serum albumin level less than 30g/L
- Intraoperative use of clonidine or dexmedetomidine
- Patient requiring postoperative mechanical ventilation
- Difficulties in using patient-controlled analgesia
- Pregnancy
- Current or previous drug abuser
- Alcoholism
- Patient refusal
Key Trial Info
Start Date :
April 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00942565
Start Date
April 1 2007
End Date
December 1 2012
Last Update
February 1 2013
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Anaesthesiology, The University of Hong Kong
Hong Kong, Hong Kong